Achieving high selectivity among different nucleophiles has been a hard nut to crack in Cu-catalyzed Ullmann C–O and C–N couplings. The cover art of the Journal of Organic Chemistry illustrates that a precise selection of the auxiliary ligand is the key to achieving orthogonal selectivities in the arylation of mixed nucleophiles. In a similar manner, selection of the best green nuts and herbs is the key for production of the best ratafia, the most famous liqueur in Catalonia.
The paper by Xavi Ribas and co-workers was published today:
M. Rovira, M. Soler, I. Güell, M. Wang, L. Gómez, and X. Ribas
“Orthogonal Discrimination among Functional Groups in Ullmann-Type C–O and C–N Couplings”
J. Org. Chem. 2016, 81, 7315-7325 [abstract]