Allostery is a central mechanism for the regulation of multi-enzyme complexes. The mechanistic basis that drives allosteric regulation is poorly understood but harbors key information for enzyme engineering. In the present study, we focus on the tryptophan synthase complex that is composed of TrpA and TrpB subunits, which allosterically activate each other. Specifically, we develop
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News
The IQCC started a new series of online talks to address challenges in the research fields where the IQCC is playing a role, through the investigations of one of the Principal Investigators. An external expert is invited to give a seminar, together with one of the junior researchers of the IQCC. These complementary views will highlight the current state-of-the-art
Modulation of a mu-1,2-Peroxo Dicopper(II) Intermediate by Strong Interaction with Alkali Metal Ions
The properties of metal/dioxygen species, key intermediates in oxidation catalysis, can be modulated by interaction with redox-inactive Lewis acids, but structural information about these adducts is scarce. Here we demonstrate that even mildly Lewis acidic alkali metal ions, which are typically viewed as innocent “spectators”, bind strongly to a reactive cis-peroxo dicopper(II) intermediates. Unprecedented structural
Next Friday (5th of November 11.00h, Aula Magna – Facultat de Ciències) will be the defense of the doctoral thesis of Margarida Borrell Recasens, titled “Small-molecule mimics of Rieske oxygenases.Application to selective aliphatic C-H hydroxylation and olefin syn-dihydroxylation”, supervised by Miquel Costas from IQCC. We wish her good luck and all the best! Girona, October
Last week, Oriol Planas, a former member of the IQCC, was appointed as a Lecturer in Organic Chemistry by Queen Mary University of London, where he will start his own research group at the School of Physical and Chemical Sciences. Oriol did his PhD thesis with success on “Cobalt-catalyzed C-H Activation” supervised by Xavi Ribas
Yesterday took place the Autumn edition of the IQCC Forum, a quarterly meeting-place where high-quality science is discussed. The IQCC Forum gives the opportunity for PhD and postdoc members of the IQCC to present their work to a select group of critical researchers, enhancing intra-IQCC collaborations and promoting knowledge exchange within the institute. This will
Dr. Marc Garcia-Borràs (IQCC) is part of an international multidisciplinary research team led by Prof. Katherine Ryan (University of British Columbia, Canada) that has recently published a new study in PNAS entitled “A shared mechanistic pathway for pyridoxal phosphate–dependent arginine oxidases”. Pyridoxal phosphate (PLP)-dependent enzymes rarely react with oxygen, but an emerging group of PLP-
The journal Chemistry-A European Journal included in the Hot Topic on C-C coupling the recently published review “Mechanistic Aspects of the Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling Reaction”. Among the different reactions that lead to the formation of C-C bonds, the Suzuki-Miyaura approach has a fundamental role, at the level of basic research and industrial applications. In particular, the palladium
Every year in September since 2008, the IQCC is organizing together with the Scientific Culture and Digital Communication (C4D) unit of the UdG, the Diputació de Girona and the Girona City Council the European Researchers’ Night with the aim to bring science closer to the Girona general public. The European Researchers’ Night is a coordianted
The journal Catalysis Science & Technology features on its front cover the recently published research article “Simultaneous screening of multiple substrates with an unspecific peroxygenase enabled modified alkane and alkene oxyfunctionalisations”, a collaboration between the research teams of Jun.-Prof. Martin Weissenborn (Leibniz Institute of Plant Biochemistry, Halle (Saale)) and Dr. Marc Garcia-Borràs. In this project,