Angewandte Chemie International Edition features on its front cover the recently published research article “Harnessing the Structure and Dynamics of the Squalene-Hopene Cyclase for (?)-Ambroxide Production”.
Ambergris is a highly valued natural product in the fragrance industry and is also known as “floating gold” because of its biosynthesis in the intestines of sperm whales. Owing to this scarce natural resource, the stereoselective synthesis of its most prominent olfactory component, (?)-ambroxide, via alternative routes is attractive. In their Research Article (e202301607), Sílvia Osuna, Bernhard Hauer et?al. demonstrate the catalytic potential of an engineered squalene-hopene cyclase in the intricate cyclization of the precursor homofarnesol. Cover art: Verena Resch, Graz.
The corresponding paper was published recently:
Andreas Schneider, Christian Curado, Thomas B. Lystbaek, Sílvia Osuna, Bernhard Hauer
Harnessing the Structure and Dynamics of the Squalene?Hopene Cyclase for (?)?Ambroxide Production**
Angew Chem Int Ed, 2023, , ASAP-
Girona, May 15, 2023
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