Since the formulation of the Hückel’s rule, a variety of rules have been proposed to determine if a molecule is aromatic. These allow chemists to better understand molecules and their behavior, as well as identify the formation or elimination of (anti)aromatic species in a reaction, which helps understand and predict possible outcomes. In this comment article, Prof. Miquel Solà first briefly discusses the most widespread rules associated with different types of aromaticity, then draws attention to their limitations, and finally propose future directions for the development of this fascinating topic.
The comment was recently published in Nature Chemistry:
Nat. Chem. 2022, 14, 585-590
Girona, June 9, 2022
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