Recently, Roger Monreal-Corona, Emili Besalú, Anna Pla-Quintana and Albert Poater reported in Organic & Biomolecular Chemistry on “Photoredox catalysis leading to triazolo-quinoxalinones at room temperature: selectivity of the rate determining step”. The interest in the fusion product of quinoxalinone skeletons and 1,2,3-triazole units has greatly increased in recent years since they are known to be
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Nature has recently published an article (by Rachael Pells) about neurodivergence featuring neurodivergent scientists. One such scientist is Dr. Ouissam El Bakouri researcher at the Institute of Computational Chemistry and Catalysis (IQCC) from the University of Girona who got interviewed (among another three) and explains and shares his challenges and experiences day to day and through
Last Friday, the IQCC organized a meeting to show the documentary Picture a Scientist and a round table with Assumpció Vila Simon, Anna Pla-Boix and Carme Font-Paz to highlight gender inequality in science during the Science Week. The film tells the stories of several prominent female researchers and brings to light the barriers that they encountered, including cases of discrimination
Every year in November, the IQCC is organizing together with the Scientific Culture and Digital Communication (C4D) unit of the UdG some activities for Science Week with the aim to bring our science closer to the Girona general public. Last Friday, November 18, 2022, the Diada de Sant Albert took place at Science Faculty of UdG. The
Last Thursday, the IQCC organized the third edition of the IndustryQCC Forum with four national and international companies (Repsol, Eli Lilly, AstraZeneca and Pfizer) during the Science Week. The IndustryQCC Forums provide young (and more advanced) researchers of IQCC the opportunity to get to know the research carried out in (bio)chemical industry in different parts of
Last Thursday took place the Autumn edition of the IQCC Forum, a quarterly meeting-place where high-quality science is discussed. The IQCC Forum gives the opportunity for PhD and postdoc members of the IQCC to present their work to a select group of critical researchers, enhancing intra-IQCC collaborations and promoting knowledge exchange within the institute. This
Next Friday will be the defense of the doctoral thesis of Ernest Ubasart Clarà, titled “Synthesis and applications of large supramolecular nanocapsules: Matryoshka-type masks, higher fullerene C84 purification and stabilization of metallic clusters and sub-namoparticles”, supervised by Xavi Ribas from IQCC. Place: Aula Magna – Facultat de Ciències Date: October 28, 2022 Time: 10.30h We wish him good luck
Methods for regioselective N-methylation and -alkylation of unsaturated heterocycles with “off the shelf” reagents are highly sought-after. This reaction could drastically simplify synthesis of privileged bioactive molecules. Here we report engineered and natural methyltransferases for challenging N-(m)ethylation of heterocycles, including benzimidazoles, benzotriazoles, imidazoles and indazoles. The reactions are performed through a cyclic enzyme cascade that consists of
In this research article, we describe a 4H+/4e– electron-coupled-proton buffer (ECPB) based on Cu and a redox-active ligand. The protonated/reduced ECPB (complex 1: [Cu(8H+/14e–)]1+), consisting of CuI with 2 equiv of the ligand (catLH4: 1,1?-(4,5-dimethoxy-1,2-phenylene)bis(3-(tert-butyl)urea)), reacted with H+/e– acceptors such as O2 to generate the deprotonated/oxidized ECPB. The resulting compound, (complex 5: [Cu(4H+/10e–)]1+), was characterized
The aerobic oxidation of alkenes to carbonyls is an important and challenging transformation in synthesis. Recently, a new P450-based enzyme (aMOx) has been evolved in the laboratory to directly oxidize styrenes to their corresponding aldehydes with high activity and selectivity. The enzyme utilizes a heme-based, high-valent iron-oxo species as a catalytic oxidant that normally epoxidizes