Introduction Since 1993 the Institut de Química Computacional i Catàlisi (IQCC) has been organizing the biannual series of conferences called the Girona Seminars. The early editions (until 2003) were focused on molecular similarity (main organizer Prof. Ramon Carbó-Dorca), which changed in 2006 when every new edition a different topic was chosen (main organizer Prof. Miquel