Xavi Ribas

Sustainable C-H functionalization catalysis and Supramolecular chemistry at the confined space of nanocapsules.

Contact info:
Dr. Xavi Ribas
xavi.ribas@udg.edu
Tel. (+34) 972 41 91 94
Website

XaviRibas

Selected publications

Oriol Planas, Xavi Ribas* et al.
Carboxylate-Assisted Formation of Aryl-Co(III) Masked-Carbenes in Cobalt-Catalyzed C-H Functionalization with Diazo Esters
J. Am. Chem. Soc., 2017, 139, 14649?14655
DOI: 10.1021/jacs.7b07880

J. Serra, X. Ribas*, D. Bourissou* et al.
Cyclometalated gold(III) complexes: noticiable differences between (N,C) and (P,C) ligands in migratory insertion
Chem. Sci., 2018, 9, 3932.
DOI: 10.1039/C7SC04899H

Lorena Capdevila, Xavi Ribas* et al.
Chemodivergent Nickel(0)-Catalyzed Arene C-F Activation with Alkynes: Unprecedented C-F/C-H Double Insertion
ACS Catal., 2019, 9, 11074?11081
DOI: 10.1021/acscatal.9b03620

Carles Fuertes-Espinosa, Xavi Ribas* et al.
Purification of Uranium-based Endohedral Metallofullerenes (EMFs) by Selective Supramolecular Encapsulation and Release
Angew. Chem. Int. Ed., 2018, 57, 11294-11299
DOI: 10.1002/anie.201806140

C. Fuertes, X. Ribas* et al.
Supramolecular Fullerene Sponges as Catalytic Masks for Regioselective Functionalization of C60
Chem., 2019, ASAP, ASAP
DOI: 10.1016/j.chempr.2019.10.010

+ Publications

Dr. Xavi Ribas

Xavi Ribas (1974, Santa Coloma de Farners) obtained his PhD in Chemistry at the University of Girona (UdG) in 2001, and he carried out a 3-year postdoc at ICMAB-CSIC in 2002-2004. He was promoted to Associate professor in Chemistry at UdG in 2006. His research over the last years has been focused on three main projects; a) Fundamental mechanistic studies on redox transition metals in organometallic cross coupling and C-H activation and functionalization of arenes, b) Study of structural and functional modelling of non-heme Fe, Mn and Cu oxygenases and its application as selective oxidation catalysts, c) development of nanocapsules for catalysis at the confined space, host-guest reactions and purification of fullerenes and endohedral metallofullerenes (EMFs).

He was awarded with an ICREA-Acadèmia prize in 2010, and an ERC-Starting Grant in 2011 (ERC-2011-StG-277801, till Nov 2017), the latter on C-X and C-H functionalization involving Cu(III) species. Moreover, he obtained two consecutive grants from MINECO (CTQ2013-43012-P, CTQ2016-77989-P). He was awarded with a second ICREA-Acadèmia prize in 2015, and an ERC-Proof of Concept Grant in 2015 (ERC-PoC-2015-709590). He is also leading the Catalan project (2017 SGR 264), and the Univ. Girona research projects MCPUdG2016 and GdRCompetUdG2017. In 2018 he was awarded with the Premio a la Excelencia Investigadora RSEQ 2018.

His work has been published in 123 articles in peer reviewed journals. Moreover, he published 5 book chapters, filled 5 Spanish patents and he edited the book entitled “C-H and C-X functionalization. Transition metal mediation”, published by RSC-Publishing in 2013. He has communicated his work in more than 170 international conferences and he has given over 45 lectures at international conferences and universities. He is also the co-founder of the SpinOff company GIOXCAT.

Research overview

Copper-catalyzed cross-coupling reactions for the formation of aryl?heteroatom bonds (Ullmann reaction) is currently a hot topic, due to the importance of developing new sustainable synthetic tools. However, several mechanistic key aspects are still under debate. Our goal is to design new catalysts capable of effecting the desired transformations under mild conditions. A breakthrough finding of our group has been the recognition of the Cu(I)/Cu(III) catalytic redox cycle as a viable mechanism in Ullmann-type catalysis. This coupling reactivity has been extended for the first time to the other coinage metals, i.e. Ag(I)/Ag(III) and Au(I)/Au(III) catalytic cycles. Our research interests also involve the development and mechanistic understanding of C-H activation catalyzed by cheaper and less toxic first-row transition metal, especially Co and Ni. Finally, the catalytic procedures are explored in confined environments using supramolecular metallocages, including asymmetric transformations via organometallic catalysis and the purification of fullerenes and EMFs.

Sustainable C-X and C-H functionalization catalyzed by first-row transition metals.

Metal-catalyzed cross-coupling reactions for the formation of aryl?heteroatom bonds is a hot topic, due to the importance of developing new sustainable synthetic tools. However, several mechanistic key aspects are still under debate. Our goal is to design new catalysts capable of effecting the desired transformations under mild conditions. A breakthrough finding of our group has been the recognition of the Cu(I)/Cu(III) catalytic redox cycle as a viable mechanism in Ullmann-type catalysis. Analogous Ag(I)/Ag(III) and Au(I)/Au(III) redox catalysis are also under investigation. The development of more sustainable direct C-H functionalization reactions, catalyzed by transition-metals, is another enormous challenge. Our research is focused on the quest of cheaper and less toxic first-row transition metal activation of C-H bonds, with the understanding of the molecular mechanism of such transformations as a major goal.
Xavi_Ribas_research_line_1

Catalysis in the confined space

The supramolecular design of 3D nanocapsules is pursued through metal-driven self-assembly, with potential applications as reaction nanovessels and supramolecular hosts. Along this strategy, we have been able to synthesize a variety of structures that include molecular nanosized squares and rectangles, helicates and trigonal and tetragonal prismatic nanocapsules. We have been able to demonstrate the effectiveness of asymmetric hydroformylation catalyzed by anchored Rh-catalysts using metalloporphyrin-containing tetragonal prismatic nanocapsules. Moreover, the host-guest properties of nanocapsules are currently being exploited in the purification of fullerenes and EMFs, and in their regioselective functionalization by taking advantage of the use of nanocapsules as supramolecular masks.

People

Principal Investigator

Xavi Ribas

Prof. Agregat


Staff and Postdocs


PhD and MACMoM students

Carla Magallón

PhD student (IF-UdG)

Supervisor:
- A. Company
- X. Ribas

Carles Fuertes

PhD student

Supervisor:
- M. Costas
- X. Ribas

Ernest Ubasart

PhD student (STR)

Supervisor:
- X. Ribas

Lorena Capdevila

PhD student (FPI)

Supervisor:
- X. Ribas

Marco Cianfanelli

PhD student (MSCA ITN)

Supervisor:
- M. Costas
- X. Ribas

Míriam Pujals Crusat

PhD Student (IF-UdG)

Supervisor:
- X. Ribas

Pau Font

PhD student (FPU)

Supervisor:
- X. Ribas

Steven Roldán

PhD student (FPI)

Supervisor:
- Josep M. Luís
- X. Ribas


Funding

COST. COST Actions

Project: C-H Activation in Organic Synthesis (CHAOS)
Researcher: Dr. Xavi Ribas
Reference: CA 15106
Funding: Participant
Period: 2016 – 2020

ICREA Acadèmia Awards

Project: Programa ICREA Acadèmia 2015
Researcher: Dr. Xavi Ribas
Reference: ICREA Acadèmia 2015
Funding: 205.000 €
Period: 01/01/2016 – 31/12/2020

MCIU Proyectos I+D. Proyectos I+D

Project: Model platforms for the mechanistic understanding of C-H and C-X functionalizations (MODMECH)
Researcher: Dr Xavi Ribas & Dr Anna Company
Reference: CTQ2016-77989-P
Funding: 135.000 €
Period: 2017 – 2019

MCIU. Adquisición de equipamiento científico-técnico 2018

Project: Adquisición de un espectrómetro de masas MALDI-TOF
Researcher: X. Ribas
Reference: EQC2018-004422-P
Funding: 250.000 €
Period: 2018 – 2019

AGAUR. Suport a grups de recerca.

Project: Química Bioinspirada, Supramolecular i Catàlisi (QBIS-CAT)
Researcher: X. Ribas
Reference: 2017 SGR 264
Funding: 65.896 €
Period: 01/01/2017 – 31/12/2020

News

Two European research projects (ERC-PoC)

Recently researchers of the IQCC and research group QBIS-Cat of the University of

Xavi Ribas repeats the ICREA Acadèmia award

Today ICREA announced the list of winners of the ICREA Acadèmia awards 2015,

First Science Slam IQCC within Science Week

The Institute of Computational Chemistry and Catalysis of the University of Girona organizes the 1st Science

Seminar by Prof. Ken Sakai on Molecular photocatalysis

Today we had the pleasure of having Prof. Ken Sakai visiting the IQCC,