Publications

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Results: 6

Judith Münch, Jordi Soler, Nicole Hünecke, Dominik Homann, Marc Garcia-Borràs, Martin J. Weissenborn
Computational-Aided Engineering of a Selective Unspecific Peroxygenase toward Enantiodivergent β-Ionone Hydroxylation
ACS Catal., 2023, [], 8963-8972
DOI: 10.1021/acscatal.3c00702
Keywords: Biocatalysis, Computational chemistry, Enzyme design, Joint Exp-Comp

Lucas Schaus, Anuvab Das, Anders M. Knight, Gonzalo Jimenez-Osés, K. N. Houk, Marc Garcia-Borràs, Frances H. Arnold, Xiongyi Huang
Protoglobin‐Catalyzed Formation ofcis ‐Trifluoromethyl‐Substituted Cyclopropanes by Carbene Transfer
Angew Chem Int Ed, 2023, 62, e202208936
DOI: 10.1002/anie.202208936
Keywords: Catalysis, Computational chemistry, Enzyme design, Metalloproteins

Carla Calvó-Tusell, Zhen Liu, Kai Chen, Frances H. Arnold, Marc Garcia-Borràs
Reversing the Enantioselectivity of Enzymatic Carbene N–H Insertion Through Mechanism‐Guided Protein Engineering
Angew Chem Int Ed, 2023, 62, e202303879
DOI: 10.1002/anie.202303879
Keywords: Biocatalysis, Computational chemistry, Enzyme design, Joint Exp-Comp

Brandon J. Bloomer, Sean N. Natoli, Marc Garcia-Borràs, Jose H. Pereira, Derek B. Hu, Paul D. Adams, K. N. Houk, Douglas S. Clark, John F. Hartwig
Mechanistic and structural characterization of an iridium-containing cytochrome reveals kinetically relevant cofactor dynamics
Nat Catal, 2023, 6, 39-51
DOI: 10.1038/s41929-022-00899-9
Keywords: Catalysis, Enzyme design

Sebastian Gergel, Jordi Soler, Alina Klein, KaiH. Schülke, Bernhard Hauer, Marc Garcia-Borràs, StephanC. Hammer
Engineered cytochrome P450 for direct arylalkene-to-ketone oxidation via highly reactive carbocation intermediates
Nat Catal, 2023, 6, 606-617
DOI: 10.1038/s41929-023-00979-4
Keywords: Biocatalysis, Computational chemistry, Enzyme design, Joint Exp-Comp, Sustainable Catalysis

Marc Garcia-Borràs
Photobiocatalysts tame nitrogen-centred radicals
Nat Catal, 2023, 6, 654-656
DOI: 10.1038/s41929-023-01004-4
Keywords: Biocatalysis, Enzyme design