Publications

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Results: 116

Sabrina Mandl, Janet Sánchez, Miquel Estévez, Astrid Bruckmann, Caroline Hiefinger, Sílvia Osuna, Andrea Hupfeld
Boosting Reversible Photocontrol of a Photoxenase by an Engineered Conformational Shift
Angew Chem Int Ed, 2026, 65, e18896
DOI: 10.1002/anie.202518896
OpenAccess: Link
Keywords: Enzyme design

Kavita G. Ramnath, Colin T. Pierce, Guillem Casadevall, Silvia Osuna, Jadyn Ide‐Pech, Bryan Zeng, Vishnu Iyer, Romas J. Kazlauskas, Richard A. Gross
Engineered Leaf‐Branch Compost Cutinase with Enhanced PET Degradation Across a Broad Temperature Range
ChemSusChem, 2026, 19, ASAP-
DOI: 10.1002/cssc.202501789
OpenAccess: Link
Keywords: Enzyme design

Sophie Staar, Miquel Estévez-Gay, Felix Kaspar, Sílvia Osuna, Anett Schallmey
Engineering of Conserved Sequence Motif 1 Residues in Halohydrin Dehalogenase HheC Simultaneously Enhances Activity, Stability, and Enantioselectivity
ACS Catal., 2025, 15, 5257-5272
DOI: 10.1021/acscatal.5c00819
OpenAccess: Link
Keywords: Enzyme design

Mona Wieland, Jonnely Luizaga, Cristina Duran, Barbara Germscheid, Johanna Rein, Astrid Bruckmann, Caroline Hiefinger, Sílvia Osuna, Andrea Hupfeld
Reversible Substrate-Specific Photocontrol of the Chemotherapeutic Asparaginase(-Glutaminase) fromEscherichia coli
ACS Catal., 2025, 15, 8462-8478
DOI: 10.1021/acscatal.5c01608
OpenAccess: Link
Keywords: Enzyme design

Tobias Vornholt, Peter Stockinger, Mojmír Mutný, Markus Jeschek, Bettina Nestl, Gustav Oberdorfer, Sílvia Osuna, Jürgen Pleiss, Ditte Hededam Welner, Andreas Krause, Rebecca Buller, Thomas R. Ward
Of Revolutions and Roadblocks: The Emerging Role of Machine Learning in Biocatalysis
ACS Cent. Sci., 2025, 11, 1828–1838
DOI: 10.1021/acscentsci.5c00949
OpenAccess: Link
Keywords: Enzyme design

Jiacheng Li, Cristina Duran, Balázs Pogrányi, Katy A.S. Cornish, Jared Cartwright, Sílvia Osuna, William P. Unsworth, Gideon Grogan
Divergent Oxidation Reactions ofE ‐ andZ ‐Allylic Primary Alcohols by an Unspecific Peroxygenase
Angew Chem Int Ed, 2025, 64, e202422241
DOI: 10.1002/anie.202422241
OpenAccess: Link
Keywords: Biocatalysis, Enzyme design

Caroline Hiefinger, Michela Marcon, Verena Pape, Guillem Casadevall, Ranit Lahmy, Christoph Haag, Julian Nazet, Michael Bartl, Astrid Bruckmann, Sílvia Osuna, Burkhard König, Andrea Hupfeld
Expanding the Repertoire of Photoswitchable Unnatural Amino Acids for Enzyme Engineering
Angew Chem Int Ed, 2025, 64, e202508562
DOI: 10.1002/anie.202508562
OpenAccess: Link
Keywords: Enzyme design

Hiva Doustmohammadi, Janet Sanchez, Dhani Ram Mahato, Sílvia Osuna
Evolution Enhances Kemp Eliminase Activity by Optimizing Oxyanion Stabilization and Conformational Flexibility
Chemistry A European J, 2025, 31, e202403747
DOI: 10.1002/chem.202403747
OpenAccess: Link
Keywords: Biocatalysis, Enzyme design

Esther Pruna Cortada, Sílvia Osuna
Shortest Path Map correlation-based tool for capturing functionally relevant allosteric networks and its application in enzyme design
Comptes Rendus. Chimie, 2025, 28, 383-395
DOI: 10.5802/crchim.389
OpenAccess: Link
Keywords: Biocatalysis, Enzyme design

Athul Santha Bhaskaran, Sílvia Osuna, Marcel Swart
Computational Exploration of Xe Dimers Inside Fullerene Cages
J. Phys. Chem. A, 2025, 129, 7609-7616
DOI: 10.1021/acs.jpca.5c02438
OpenAccess: Link
Keywords: Enzyme design