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Results: 12

Lucas Schaus, Anuvab Das, Anders M. Knight, Gonzalo Jimenez-Osés, K. N. Houk, Marc Garcia-Borràs, Frances H. Arnold, Xiongyi Huang
Protoglobin‐Catalyzed Formation ofcis ‐Trifluoromethyl‐Substituted Cyclopropanes by Carbene Transfer
Angew Chem Int Ed, 2023, 62, e202208936
DOI: 10.1002/anie.202208936
OpenAccess: –
Keywords: Catalysis, Computational chemistry, Enzyme design, Metalloproteins

Yue Fu, Heyu Chen, Wenzhen Fu, Marc Garcia-Borràs, Yang Yang, Peng Liu
Engineered P450 Atom-Transfer Radical Cyclases are Bifunctional Biocatalysts: Reaction Mechanism and Origin of Enantioselectivity
J. Am. Chem. Soc., 2022, 144, 13344-13355
DOI: 10.1021/jacs.2c04937
OpenAccess: –
Keywords: Catalysis, Computational chemistry, Confined space, Enzyme design, Metalloproteins

Jordi Soler, Sebastian Gergel, Cindy Klaus, StephanC. Hammer, Marc Garcia-Borràs
Enzymatic Control over Reactive Intermediates Enables Direct Oxidation of Alkenes to Carbonyls by a P450 Iron-Oxo Species
J. Am. Chem. Soc., 2022, 144, 15954-15968
DOI: 10.1021/jacs.2c02567
OpenAccess: Link
Keywords: Catalysis, Computational chemistry, Confined space, Enzyme design, Metalloproteins

Zhen Liu, Zi-Yang Qin, Ledong Zhu, Soumitra V. Athavale, Arkajyoti Sengupta, Zhi-Jun Jia, Marc Garcia-Borràs, K.N. Houk, FrancesH. Arnold
An Enzymatic Platform for Primary Amination of 1-Aryl-2-alkyl Alkynes
J. Am. Chem. Soc., 2022, 144, 80-85
DOI: 10.1021/jacs.1c11340
OpenAccess: –
Keywords: Enzyme design, Metalloproteins

Jinyan Rui, Qun Zhao, AnthonyJ. Huls, Jordi Soler, JaredC. Paris, Zhenhong Chen, Viktor Reshetnikov, Yunfang Yang, Yisong Guo, Marc Garcia-Borràs, Xiongyi Huang
Directed evolution of nonheme iron enzymes to access abiological radical-relay C(sp³ )−H azidation
Science, 2022, 376, 869-874
DOI: 10.1126/science.abj2830
OpenAccess: –
Keywords: Computational chemistry, Enzyme design, Metalloproteins, Predictive Chemistry, Reaction mechanisms

Anja Knorrscheidt, Jordi Soler, Nicole Hünecke, Pascal Püllmann, Marc Garcia-Borràs, and Martin J. Weissenborn
Accessing Chemo- and Regioselective Benzylic and Aromatic Oxidations by Protein Engineering of an Unspecific Peroxygenase
ACS Catal., 2021, 11, 7327-7338
DOI: 10.1021/acscatal.1c00847
OpenAccess: –
Keywords: Catalysis, Computational chemistry, Enzyme design, Metalloproteins, Oxidation

Manfred T. Reetz, Marc Garcia-Borràs
The Unexplored Importance of Fleeting Chiral Intermediates in Enzyme-Catalyzed Reactions
J. Am. Chem. Soc., 2021, 143, 14939-14950
DOI: 10.1021/jacs.1c04551
OpenAccess: Link
Keywords: Catalysis, Enzyme design, Metalloproteins, Reaction mechanisms

Marc Garcia-Borràs, S.B.Jennifer Kan, RussellD. Lewis, Allison Tang, Gonzalo Jimenez-Osés, FrancesH. Arnold, K.N. Houk
Origin and Control of Chemoselectivity in Cytochromec Catalyzed Carbene Transfer into Si–H and N–H bonds
J. Am. Chem. Soc., 2021, 143, 7114-7123
DOI: 10.1021/jacs.1c02146
OpenAccess: –
Keywords: Catalysis, Computational chemistry, Enzyme design, Metalloproteins

Zhen Liu, Carla Calvó-Tusell, AndrewZ. Zhou, Kai Chen, Marc Garcia-Borràs, Frances H. Arnold
Dual-function enzyme catalysis for enantioselective carbon–nitrogen bond formation
Nat. Chem., 2021, 13, 1166-1172
DOI: 10.1038/s41557-021-00794-z
OpenAccess: –
Keywords: Catalysis, Computational chemistry, Enzyme design, Metalloproteins

Kristína Urbanová, Inmaculada Ramírez-Macías, Rubén Martín-Escolano, María Rosales, Olaf Cussó, Joan Serrano, Anna Company, Manuel Sánchez-Moreno, Miquel Costas, Xavi Ribas, Clotilde Marín
Effective Tetradentate Compound Complexes against Leishmania spp. that Act on Critical Enzymatic Pathways of These Parasites
Molecules, 2019, 24, 134-
DOI: 10.3390/molecules24010134
OpenAccess: Link
Keywords: Catalysis, High-valent metal complexes, Metalloproteins, Oxidation