Feixas, Ferran

ACCEMBLY: Accelerating (Bio)molecular Recognition, Assembly, and Catalysis

Contact info:
Dr. Ferran Feixas
Tel. (+34) 650 28 71 48


Selected publications

Antonia Tomás-Loba, Elisa Manieri, Bárbara González-Terán, Alfonso Mora, Luis Leiva-Vega, Ayelén M. Santamans, Rafael Romero-Becerra, Elena Rodríguez, Aránzazu Pintor-Chocano, Ferran Feixas, Juan Antonio López, Beatriz Caballero, Marianna Trakala, Óscar Blanco, Jorge L. Torres, Lourdes Hernández-Cosido, Valle Montalvo-Romeral, Nuria Matesanz, Marta Roche-Molina, Juan Antonio Bernal, Hannah Mischo, Marta León, Ainoa Caballero, Diego Miranda-Saavedra, Jesús Ruiz-Cabello, Yulia A. Nevzorova, Francisco Javier Cubero, Jerónimo Bravo, Jesús Vázquez, Marcos Malumbres, Miguel Marcos, Sílvia Osuna & Guadalupe Sabio
p38γ is essential for cell cycle progression and liver tumorigenesis
Nature, 2019, 568, 557-560
DOI: 10.1038/s41586-019-1112-8

Christian Curado-Carballada, Ferran Feixas, Javier Iglesias-Fernández, Sílvia Osuna
Hidden Conformations inAspergillus niger Monoamine Oxidase are Key for Catalytic Efficiency
Angew. Chem. Int. Ed., 2019, 58, 3097-3101
DOI: 10.1002/anie.201812532

Xavier Arqué, Adrian Romero-Rivera, Ferran Feixas, Tania Patiño, Sílvia Osuna, Samuel Sánchez
Intrinsic enzymatic properties modulate the self-propulsion of micromotors
Nat Commun, 2019, 10, 2826
DOI: 10.1038/s41467-019-10726-8

Yinglong Miao, Ferran Feixas, Changsun Eun, J.Andrew McCammon
Accelerated molecular dynamics simulations of protein folding
J. Comput. Chem., 2015, 36, 1536-1549
DOI: 10.1002/jcc.23964

Ouissam El Bakouri, Verònica Postils, Marc Garcia-Borràs, Miquel Duran, Josep M. Luis, Simone Calvello, Alessandro Soncini, Eduard Matito, Ferran Feixas, Miquel Solà
Metal Cluster Electrides: a new Type of Molecular Electrides with Delocalised Polyattractor Character
Chem. Eur. J., 2018, 24, 9853-9859
DOI: 10.1002/chem.201800878

+ Publications

Dr. Ferran Feixas

Ferran Feixas (1983) obtained his PhD in Chemistry with academic honors at the University of Girona under the supervision of Prof. Miquel Sola?, Prof. Jordi Poater, and Dr. Eduard Matito. In this period, he carried out research stays in France, Czech Republic, Germany, and Poland. Upon graduation, he moved to the University of California, San Diego (USA), for a two-year postdoctoral position with a Beatriu de Pino?s fellowship at the Prof. J. Andrew McCammon group. In 2014, he joined the IQCC with a reintegration Beatriu de Pino?s fellowship and, in 2015, was awarded with the Marie Curie Individual Fellowship (IF-EF, MetAccembly). In 2019, he was awarded a three-year Retos Investigación project (RTI2018-101032-J-I00) for developing and applying novel simulation based techniques with applications in the field of biochemistry and supramolecular chemistry (Accembly). In 2019, thanks to the EU and MICINN contribution (MetAccembly IF-EF and RTI2018), he initiated his independent career as Principal Investigator at the IQCC (UdG). He has co-authored 44 publications in international journals.

Research overview

(Bio)molecular recognition and assembly are key concepts in biochemistry, drug design, and supramolecular chemistry. Chemical and life processes are critically dependent on the association and dissociation of (bio)molecules. The pathways that drive recognition, assembly, and dissociation are strongly influenced by the dynamic nature of the interacting partners. A deep understanding of the mechanisms of these relevant processes is of utmost importance. The goal of our group is to develop and apply computational tools to unravel the details of association and dissociation pathways of (bio)molecules to gain insight into the detailed molecular mechanisms of relevant chemical and biomedical processes and, then, harness this information to enhance the discovery and rational design of novel drugs, protein assemblies, supramolecular complexes, and/or (bio)catalysts.
We focus on the development and application of enhanced sampling methods for the study of molecular recognition, assembly and catalysis.
– Drug Design: Reconstruction of drug binding and unbinding pathways.
– Enzymes Catalysis / Enzyme Design: molecular basis of enzyme catalysis, allosteric regulation, and enzyme evolution and engineering.
– Supramolecular Chemistry: dynamic reconstruction of molecular recognition in supramolecular complexes (nanohosts and cavitands)
– Photopharmacology: deciphering the molecular basis of allosteric photoswitches in G-Protein Coupled Receptors.


Principal Investigator

Ferran Feixas

Ramón y Cajal Researcher

Staff and Postdocs

PhD and MACMoM students

Aqza Elza John

PhD student (FPI)

- F. Feixas
- M. Garcia-Borràs

Clara Sabrià

PhD Student (FI)

- F. Feixas
- X. Ribas

Cristina Berga

PhD Student (IF-UdG)

- M. García-Borràs
- F. Feixas
- S. Simon

Hande Abes

PhD student (FI)

- F. Feixas
- M. García-Borras

Helena Giramé

PhD Student (FI)

- M. García-Borràs
- F. Feixas


MCIU projects

Project: Modelado Computacional Integrativo de Procesos Bioquímicos y Biocatalíticos: Desde la Comprensión hasta el Diseño
Researcher: Dr. Marc Garcia-Borràs and Dr. Ferran Feixas
Reference: PID2022-141676NB-I00
Funding: 168.750 €
Period: 01/09/2023 – 31/08/2026
Project: Diseño y caracterización computacional de fotoelectro-biocatalisis heterogenea soportada por fotoelectrodos
Researcher: Dr. Ferran Feixas and Dr. Marc Garcia-Borràs
Reference: TED2021-130173B-C42
Funding: 125.350 €
Period: 01/12/2022 – 30/11/2024

Ramón y Cajal

Project ID: Programa Ramón y Cajal
Researcher: Dr. Ferran Feixas
Reference: RYC2020-029552-I
Funding: 324.250 €
Period: 01/03/2022 – 28/02/2027

Other projects.

Project: Fundació Institut Jaume Vicens Vives de Girona
Researcher: Dr. Ferran Feixas
Funding: 38.400 €
Period: 2023-2027


Chemistry Department open doors

Last 20th March the Chemistry Department of the University of Girona opened its doors and

Cover JACS on supramolecular masks

The JACS journal features on its inside inner cover the recently published research article “Regioswitchable Bingel

Regioswitchable Bingel Bis-Functionalization of Fullerene C70 via Supramolecular Masks

Isomer-pure functionalized fullerenes are required to boost the development of fullerene chemistry in