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2020

Enzyme Conformation Influences the Performance of Lipase‐powered Nanomotors

Authors: Lei Wang, Marzia Marciello, Miquel Estévez‐Gay, Paul E. D. Soto Rodriguez, Yurena Luengo Morato, Javier Iglesias‐Fernández, Xin Huang, Sílvia Osuna, Marco Filice, Samuel Sánchez

Angewandte Chemie International Edition, 2020, 59, 47, 21080-21087

DOI: 10.1002/anie.202008339

Keywords: Biocatalysis, Molecular Dynamics, Non-covalent interactions

Mutational Analysis of Linalool Dehydratase Isomerase Suggests That Alcohol and Alkene Transformations Are Catalyzed Using Noncovalent Mechanisms

Authors: Anibal Cuetos, Javier Iglesias-Fernández, Hamid-Reza Danesh-Azari, Erna Zukic, Adam Dowle, Sílvia Osuna, Gideon Grogan

ACS Catalysis, 2020, 10, 19, 11136-11146

DOI: 10.1021/acscatal.0c02958

Keywords: Biocatalysis, Molecular Dynamics, Non-covalent interactions

2019

Deciphering the Allosterically Driven Conformational Ensemble in Tryptophan Synthase Evolution

Authors: Miguel A. Maria-Solano, Javier Iglesias-Fernández, Sílvia Osuna

Journal of the American Chemical Society, 2019, 141, 33, 13049-13056

DOI: 10.1021/jacs.9b03646

Keywords: Biocatalysis, Molecular Dynamics, Non-covalent interactions

Intrinsic enzymatic properties modulate the self-propulsion of micromotors

Authors: Xavier Arqué, Adrian Romero-Rivera, Ferran Feixas, Tania Patiño, Sílvia Osuna, Samuel Sánchez

Nature Communications, 2019, 10, 1

DOI: 10.1038/s41467-019-10726-8

Keywords: Biocatalysis, Molecular Dynamics, Non-covalent interactions

Hidden Conformations in Aspergillus niger Monoamine Oxidase are Key for Catalytic Efficiency

Authors: Christian Curado‐Carballada, Ferran Feixas, Javier Iglesias‐Fernández, Sílvia Osuna

Angewandte Chemie International Edition, 2019, 58, 10, 3097-3101

DOI: 10.1002/anie.201812532

Keywords: Biocatalysis, Molecular Dynamics, Non-covalent interactions

Efficient reductive desymmetrization of bulky 1,3-cyclodiketones enabled by structure-guided directed evolution of a carbonyl reductase

Authors: Xi Chen, Hongliu Zhang, Miguel A. Maria-Solano, Weidong Liu, Juan Li, Jinhui Feng, Xiangtao Liu, Sílvia Osuna, Rey-Ting Guo, Qiaqing Wu, Dunming Zhu, Yanhe Ma

Nature Catalysis, 2019, 2, 10, 931-941

DOI: 10.1038/s41929-019-0347-y

Keywords: Biocatalysis, Molecular Dynamics, Non-covalent interactions