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Results: 80

Cristina Duran, Sílvia Osuna
Inactive but Essential: The Role of the Inactive State of E49 in the Mechanism of the Alpha Subunit of Tryptophan Synthase and Its Stand-Alone BlueprintZm BX1
ACS Catal., 2026, 16, 3628-3636
DOI: 10.1021/acscatal.5c08026
OpenAccess: Link
Keywords: Enzyme design

Bethan S. Jones, Jordi Soler, Joseph W. Sharratt, Bethany N. Hogg, Michele Tavanti, Christian Schnepel, Nico Kress, Lisa S. Seibt, Sílvia Osuna, Marc Garcia-Borràs, Sabine L. Flitsch
Mechanistic Insight-Guided Protein-Engineering Strategies Lead to the Control of Cytochrome-P450-Mediated Regioselectivity of Midchain Fatty Acid C–H Activation
ACS Catal., 2026, 16, 6673-6684
DOI: 10.1021/acscatal.5c09172
OpenAccess: –
Keywords: Biocatalysis, Computational chemistry, Enzyme design

Lukas Drexler, Cristina Duran, Sílvia Osuna, Reinhard Sterner
The Discovery ofN ² ,N ² -Dimethylguanine Hydrolases Unravels General Molecular Principles of Enzyme Evolvability and Promiscuity
ACS Catal., 2026, 16, 6865-6879
DOI: 10.1021/acscatal.6c00436
OpenAccess: Link
Keywords: Enzyme design

Florian Weissensteiner, Cristina Berga, Emilia Iglesias-Moncayo, Sara Salehi, Isabel Oroz-Guinea, Klaus Zangger, Ferran Feixas, Marc Garcia-Borràs, Wolfgang Kroutil, Christoph K. Winkler
Establishing the Fatty Acid PhotodecarboxylaseCv FAP as a Platform for Photobiocatalytic Radical Transformations
ACS Catal., 2026, 16, 7758–7770
DOI: 10.1021/acscatal.6c01333
OpenAccess: Link
Keywords: Biocatalysis, Computational chemistry, Enzyme design

Jona T. Schelle, JulianL. Wissner, Isabell Muth, Carla Calvó‐Tusell, Jonathan Berger, Marc Garcia‐Borràs, Gloria Saab‐Rincón, Bernhard Hauer
Engineering Cumene Dioxygenase for Regioselective Hydroxylation of Monoterpenes and Monoterpenoids
Adv Synth Catal, 2026, 368, ASAP-
DOI: 10.1002/adsc.70323
OpenAccess: Link
Keywords: Biocatalysis, Computational chemistry, Enzyme design, Sustainable Catalysis

Qing‐Qing Zeng, Cristina Berga, Carla Calvó‐Tusell, Marc Garcia‐Borràs, Zhen Liu
Redirecting a Native Ene‐Reductase Toward Desaturation With Reverse Enantioselectivity
Angew Chem Int Ed, 2026, [], ASAP-
DOI: 10.1002/anie.3155545
OpenAccess: Link
Keywords: Biocatalysis, Computational chemistry, Enzyme design, Molecular Dynamics interactions

Sabrina Mandl, Janet Sánchez, Miquel Estévez, Astrid Bruckmann, Caroline Hiefinger, Sílvia Osuna, Andrea Hupfeld
Boosting Reversible Photocontrol of a Photoxenase by an Engineered Conformational Shift
Angew Chem Int Ed, 2026, 65, e18896
DOI: 10.1002/anie.202518896
OpenAccess: Link
Keywords: Enzyme design

Kavita G. Ramnath, Colin T. Pierce, Guillem Casadevall, Silvia Osuna, Jadyn Ide‐Pech, Bryan Zeng, Vishnu Iyer, Romas J. Kazlauskas, Richard A. Gross
Engineered Leaf‐Branch Compost Cutinase with Enhanced PET Degradation Across a Broad Temperature Range
ChemSusChem, 2026, 19, e202501789
DOI: 10.1002/cssc.202501789
OpenAccess: Link
Keywords: Enzyme design

Morito Sakuma, Dhani Ram Mahato, Ferran Feixas, ColinJ. Jackson, Eiji Nakata, Sílvia Osuna, Nobuhiko Tokuriki
Single-molecule kinetic exploration of functional sub-states in an evolving phosphotriesterase
Nat Commun, 2026, [], ASAP-
DOI: 10.1038/s41467-026-72534-1
OpenAccess: Link
Keywords: Enzyme design

Judith Münch, Jordi Soler, Ofir Gildor-Cristal, Sarel J. Fleishman, Marc Garcia-Borràs, Martin J. Weissenborn
Computationally Designed Peroxygenases That Exhibit Diverse and Selective Terpene Oxyfunctionalization
ACS Catal., 2025, [], 12741-12755
DOI: 10.1021/acscatal.5c02412
OpenAccess: Link
Keywords: Biocatalysis, Computational chemistry, Enzyme design