Results: 27
Christian Curado-Carballada, Ferran Feixas, Javier Iglesias-Fernández, Sílvia Osuna
Hidden Conformations inAspergillus niger Monoamine Oxidase are Key for Catalytic Efficiency
Angew. Chem. Int. Ed., 2019, 58, 3097-3101
DOI: 10.1002/anie.201812532OpenAccess: LinkKeywords: Molecular Dynamics, Biocatalysis, Non-covalent interactions
Miguel A. Maria-Solano, Javier Iglesias-Fernández, Sílvia Osuna
Deciphering the Allosterically Driven Conformational Ensemble in Tryptophan Synthase Evolution
J. Am. Chem. Soc., 2019, 141, 13049-13056
DOI: 10.1021/jacs.9b03646OpenAccess: –Keywords: Molecular Dynamics, Biocatalysis, Non-covalent interactions
Xi Chen, Hongliu Zhang, Miguel A. Maria-Solano, Weidong Liu, Juan Li, Jinhui Feng, Xiangtao Liu, Sílvia Osuna, Rey-Ting Guo, Qiaqing Wu, Dunming Zhu, Yanhe Ma
Efficient reductive desymmetrization of bulky 1,3-cyclodiketones enabled by structure-guided directed evolution of a carbonyl reductase
Nat Catal, 2019, 2, 931-941
DOI: 10.1038/s41929-019-0347-yOpenAccess: –Keywords: Molecular Dynamics, Biocatalysis, Non-covalent interactions
Xavier Arqué, Adrian Romero-Rivera, Ferran Feixas, Tania Patiño, Sílvia Osuna, Samuel Sánchez
Intrinsic enzymatic properties modulate the self-propulsion of micromotors
Nat Commun, 2019, 10, 2826
DOI: 10.1038/s41467-019-10726-8OpenAccess: LinkKeywords: Molecular Dynamics, Biocatalysis, Non-covalent interactions
Miguel A. Maria-Solano, Eila Serrano-Hervás, Adrian Romero-Rivera, Javier Iglesias-Fernández, Sílvia Osuna
Role of conformational dynamics in the evolution of novel enzyme function
Chem. Commun., 2018, 54, 6622-6634
DOI: 10.1039/C8CC02426JOpenAccess: –Keywords: Molecular Dynamics, Biocatalysis, Non-covalent interactions
Eila Serrano-Hervás, Guillem Casadevall, Marc Garcia-Borràs, Ferran Feixas, Sílvia Osuna
Epoxide Hydrolase Conformational Heterogeneity for the Resolution of Bulky Pharmacologically Relevant Epoxide Substrates
Chem. Eur. J., 2018, 24, 12254-12258
DOI: 10.1002/chem.201801068OpenAccess: –Keywords: Molecular Dynamics, Biocatalysis, Non-covalent interactions
Adrian Romero-Rivera, Javier Iglesias-Fernández, Sílvia Osuna
Exploring the Conversion of a
Eur. J. Org. Chem., 2018, 2018, 2603-2608
DOI: 10.1002/ejoc.201800103OpenAccess: –Keywords: Molecular Dynamics, Biocatalysis, Non-covalent interactions